The newest Indiana Jones adventure begins in the desert Southwest in 1957 – the height of the Cold War. Indy and his sidekick Mac, have barely escaped a close scrape with nefarious Soviet agents on a remote airfield.
Now, Professor Jones has returned home to Marshall College – only to find things have gone from bad to worse. The dean of the college (Jim Broadbent) explains that Indy's recent activities have made him the object of suspicion, and that the government wants the university to fire him. On his way out of town, Indiana meets rebellious Mutt (Shia LaBeouf), who offers a proposition to the adventurous archeologist: If he'll help Mutt on a mission with deeply personal stakes, Indy could make one of the most spectacular archaeological finds in history: the Crystal Skull of Akator.
But as Indy and Mutt set out on their journey, they quickly realize they are not alone in their search. The Soviet agents are also hot on the trail of the Crystal Skull. Chief among them is icy cold, devastatingly beautiful Irina Spalko (Cate Blanchett), whose elite military unit is scouring the globe for the eerie Crystal Skull, which they believe can help the Soviets dominate the world … if they can unlock its secrets.
Indy and Mutt must find a way to evade the ruthless Soviets and stop the powerful Crystal Skull from falling into the deadliest of hands.