Chloe (voice of Drew Barrymore) a diamond-clad, bootie wearing Beverly Hills Chihuahua enjoys her luxurious life so much, she hardly notices Papi (voice of George Lopez), a tough looking Chihuahua who happens to be head-over-paws for the pampered pooch.
But when Chloe gets lost in the rough streets of Mexico with only a street-wise German Shepherd (voice of Andy Garcia) to help her find her way home, Papi heads south of the border – joining forces with a motley crew: two humans, a sly rat and a nervous iguana – to rescue his true love.
